منابع مشابه
LYMPHOID NEOPLASIA Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia
1Department of Pediatrics, Division of Hematology and Oncology, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA; 2Department of Laboratory Medicine and 3Department of Pediatrics, University of California, San Francisco, CA; 4Centre for Blood Research, Faculty of Medicine, Division of Hematology, University of British Columbia, British ...
متن کاملLYMPHOID NEOPLASIA Brief report Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma
We have previously generated mice deficient for Nfe213 (NF-E2 p45 related factor 3 or Nrf3), a member of the cap ‘n’ collar family of basic-leucine zipper transcription factors. To examine whether Nrf3 is involved in chemical-induced carcinogenesis, we exposed the mice to benzo[a]pyrene (B[a]P), a carcinogen found in cigarette smoke. Contrary to wild-type mice, Nrf3-null animals are highly susc...
متن کاملLYMPHOID NEOPLASIA Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
Despite advances in the treatment of acute lymphoblastic leukemia (ALL), the majority of children who relapse still die of ALL. Therefore, the development of more potent but less toxic drugs for the treatment of ALL is imperative. We investigated the effects of the mammalian target of rapamycin inhibitor, RAD001 (Everolimus), in a nonobese diabetic/severe combined immunodeficiency model of huma...
متن کاملLYMPHOID NEOPLASIA Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia
The persistence of minimal residual disease (MRD) during therapy is the strongest adverse prognostic factor in acute lymphoblastic leukemia (ALL). We developed a high-throughput sequencing method that universally amplifies antigenreceptor gene segments and identifies all clonal gene rearrangements (ie, leukemiaspecific sequences) at diagnosis, allowing monitoring of disease progression and clon...
متن کاملLYMPHOID NEOPLASIA Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia
1Clinical Chemistry, Erasmus University Medical Center (Erasmus MC), Rotterdam; 2Pediatric Oncology/Hematology, Erasmus MC–Sophia, Rotterdam; 3Pediatric Oncology/Hematology, Beatrix Children’s Hospital, University of Groningen and University Medical Center Groningen, Groningen; 4Pediatric Oncology/Hematology, Vrije Universiteit (VU) University Medical Center, Amsterdam; 5Rheumatology, VU Univer...
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ژورنال
عنوان ژورنال: Deutsches Aerzteblatt Online
سال: 2010
ISSN: 1866-0452
DOI: 10.3238/arztebl.2010.0148b